David W. Killilea* and Bruce N. Ames*


Nutrition and Metabolism Center, Children’s Hospital Oakland Research Institute, Oakland, CA 94609; and Department of Molecular and Cellular Biology, University of California, Berkeley, CA 94720


Contributed by Bruce N. Ames, February 1, 2008 (sent for review December 3, 2007)


Magnesium inadequacy affects more than half of the U.S. population and is associated with increased risk for many age-related diseases, yet the underlying mechanisms are unknown. Altered cellular physiology has been demonstrated after acute exposure to severe magnesium deficiency, but few reports have addressed the consequences of long-term exposure to moderate magnesium deficiency in human cells…



Versión completa pdf:

Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts.

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